人霍奇金淋巴瘤细胞KM-H2

细胞名称

人霍奇金淋巴瘤细胞KM-H2

货物编码

BFN60810799

产品规格

T25培养瓶x1

1.5ml冻存管x2

细胞数量

1x10^6

1x10^6

保存温度

37℃

-198℃

运输方式

常温保温运输

干冰运输

安全等级

1

用途限制

仅供科研   3类

培养体系

DMEM(HYCLONE SH30022.01)+10%FBS+1%三抗

培养温度

37℃

二氧化碳浓度

5%

简介

人霍奇金淋巴瘤细胞KM-H2取自37岁男性供体，悬浮培养。

注释

Part of: Cancer Cell Line Encyclopedia (CCLE) project.

Part of: COSMIC cell lines project.

Part of: LL-100 blood cancer cell line panel.

Part of: MD Anderson Cell Lines Project.

Doubling time: ~48 hours (DSMZ).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Cell surface proteome.

Omics: Deep exome analysis.

Omics: Deep RNAseq analysis.

Omics: DNA methylation analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis.

Omics: Virome analysis using RNAseq.

Misspelling: KHM2/171877; In IPD-IMGT/HLA 15116.

Derived from sampling site: Pleural effusion.

基因突变

CIITA-C15orf65 gene fusion (PubMed=21368758).

PRRC2B-MGMT (BAT2L1-MGMT) gene fusion (PubMed=21368758)

HLA信息

Class I

HLA-A        A*24:02

HLA-B        B*15:01,52:01

HLA-C        C*04:01,12:02

Class II

HLA-DP        DPB1*02:01,05:01

HLA-DQ        DQA1*03:01,05:05

DQB1*03:01,03:02

HLA-DR        DRB1*04:65,11:01

DRB3*02:02

DRB4*01:03

STR信息

Amelogenin        X

CSF1PO        10,14

D5S818        11,13

D7S820        10,11,12

D13S317        10,11

D16S539        9

TH01        7,9

TPOX        8,11,12 (Cosmic-CLP)

8,10,11 (DSMZ)

vWA        17,18

参考文献

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Kamesaki H., Fukuhara S., Tatsumi E., Uchino H., Yamabe H., Miwa H., Shirakawa S., Hatanaka M., Honjo T.

Cytochemical, immunologic, chromosomal, and molecular genetic analysis of a novel cell line derived from Hodgkin's disease.

Blood 68:285-292(1986)

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Hsu S.-M., Zhao X., Chakraborty S., Liu Y.-F., Whang-Peng J., Lok M.-S., Fukuhara S.

Reed-Sternberg cells in Hodgkin's cell lines HDLM, L-428, and KM-H2 are not actively replicating: lack of bromodeoxyuridine uptake by multinuclear cells in culture.

Blood 71:1382-1389(1988)

PubMed=2602653; DOI=10.1007/978-3-642-83781-4_9

Kamesaki H., Fukuhara S., Uchino H., Nosaka T.

A new hypothesis on the cellular origin of Reed-Sternberg and Hodgkin cells based on the immunological and molecular genetic analysis of the KM-H2 line.

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Biology of Hodgkin cell lines.

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Siebert R., Willers C.P., Schramm A., Fossa A., Dresen I.M.G., Uppenkamp M., Nowrousian M.R., Seeber S., Opalka B.

Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.

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PubMed=8558920

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DOI=10.1016/B978-0-12-221970-2.50457-5

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The leukemia-lymphoma cell line factsbook.

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PubMed=17065008; DOI=10.1080/10428190600667721

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Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.

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PubMed=18194364; DOI=10.1111/j.1399-0039.2007.01001.x

Witter K., Mautner J., Volgger A., Zahn R., Kauke T.

A novel HLA-DRB1 allele, HLA-DRB1*0465, was identified in a Hodgkin's lymphoma cell line.

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PubMed=20164919; DOI=10.1038/nature08768

Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

PubMed=21368758; DOI=10.1038/nature09754

Steidl C., Shah S.P., Woolcock B.W., Rui L., Kawahara M., Farinha P., Johnson N.A., Zhao Y., Telenius A., Neriah S.B., McPherson A., Meissner B., Okoye U.C., Diepstra A., van den Berg A., Sun M., Leung G., Jones S.J., Connors J.M., Huntsman D.G., Savage K.J., Rimsza L.M., Horsman D.E., Staudt L.M., Steidl U., Marra M.A., Gascoyne R.D.

MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers.

Nature 471:377-381(2011)

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