人急性淋巴细胞白血病细胞Nalm6

细胞名称

人急性淋巴细胞白血病细胞Nalm6

货物编码

BFN60805044

产品规格

T25培养瓶x1

1.5ml冻存管x2

细胞数量

1x10^6

1x10^6

保存温度

37℃

-198℃

运输方式

常温保温运输

干冰运输

安全等级

1

用途限制

仅供科研           2类

培养体系

DMEM高糖+10%FBS+1%双抗

培养温度

37℃

二氧化碳浓度

5%

简介

人急性淋巴细胞白血病细胞Nalm6取自19岁男性供体。该细胞引种自DSMZ ACC-128

注释

Part of: Cancer Cell Line Encyclopedia (CCLE) project.

Part of: COSMIC cell lines project.

Part of: LL-100 blood cancer cell line panel.

Part of: MD Anderson Cell Lines Project.

Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.

Doubling time: 25 hours (PubMed=25984343); 19 hours (PubMed=20922763); 40.2 hours (PubMed=8847894); ~36 hours (DSMZ).

Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: Deep RNAseq analysis.

Omics: DNA methylation analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis.

Derived from sampling site: Peripheral blood.

STR信息

Amelogenin        X,Y

CSF1PO        12 (AddexBio; COG; Cosmic-CLP; DSMZ; PubMed=25877200)

12,13 (PubMed=20922763)

13 (RCB; TKG)

D2S1338        17,24

D3S1358        16,17 (COG; PubMed=25877200)

15,16,17 (PubMed=20922763)

D5S818        11 (AddexBio)

10,11,12 (COG; DSMZ; PubMed=25877200)

11,12 (Cosmic-CLP; PubMed=20922763; RCB; TKG)

D7S820        8,12 (AddexBio)

10 (COG)

8,9,10 (Cosmic-CLP; DSMZ; PubMed=25877200)

8,11,12 (PubMed=20922763)

8,11 (RCB; TKG)

D8S1179        11,13,14 (COG; PubMed=25877200)

12,13 (PubMed=20922763)

D13S317        9,11 (AddexBio)

8,9,12 (COG; DSMZ)

9,12 (Cosmic-CLP; PubMed=25877200)

9,12,13 (PubMed=20922763)

9,13 (RCB; TKG)

D16S539        11 (AddexBio)

9,10,11 (COG; DSMZ)

10,11 (Cosmic-CLP; PubMed=20922763; PubMed=25877200; RCB; TKG)

D18S51        12,15 (COG; PubMed=25877200)

11,12,14,15 (PubMed=20922763)

D19S433        13,15 (COG)

12,13,15 (PubMed=20922763)

D21S11        28,29

FGA        21,22 (COG)

22 (PubMed=11416159; PubMed=25877200)

22,23 (PubMed=20922763)

Penta D        8,14

Penta E        11

TH01        8,9 (AddexBio; COG; Cosmic-CLP; DSMZ; PubMed=20922763; RCB; TKG)

8 (PubMed=11416159; PubMed=25877200)

TPOX        8,10

vWA        15,18 (AddexBio)

15,16 (COG; Cosmic-CLP; DSMZ; PubMed=20922763; PubMed=25877200; RCB; TKG)

参考文献

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005

Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.

Characterization of human cancer cell lines by reverse-phase protein arrays.

Cancer Cell 31:225-239(2017)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5

Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747

Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3

Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x

Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.

The LL-100 panel: 100 cell lines for blood cancer studies.

Sci. Rep. 9:8218-8218(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023

Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.

Quantitative proteomics of the Cancer Cell Line Encyclopedia.

Cell 180:387-402(2020)