人T淋巴母细胞瘤细胞SUP-T1

细胞名称

人T淋巴母细胞瘤细胞SUP-T1

货物编码

BFN60811443

产品规格

T25培养瓶x1

1.5ml冻存管x2

细胞数量

1x10^6

1x10^6

保存温度

37℃

-198℃

运输方式

常温保温运输

干冰运输

安全等级

1

用途限制

仅供科研   3类

培养体系

DMEM(HYCLONE SH30022.01)+10%FBS+1%三抗

培养温度

37℃

二氧化碳浓度

5%

简介

人T淋巴母细胞瘤细胞SUP-T1取自8岁男性供体

注释

Part of: Cancer Cell Line Encyclopedia (CCLE) project.

Part of: COSMIC cell lines project.

Characteristics: Useful in studies of cell fusion and cytopathic effects of HIV-1 as well as cytopathic isolates of HIV-2.

Characteristics: Has chromosomal translocations involving the genes for the alpha and beta subunits of TCR thus preventing surface expression of the endogenous TCR complex.

Doubling time: 28 hours (PubMed=3004618); ~30 hours (DSMZ); ~24-36 hours (NIH-ARP).

Microsatellite instability: Stable (MSS) (Sanger); Instable (MSI) (PubMed=31068700).

Omics: Deep exome analysis.

Omics: Deep RNAseq analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis.

Omics: Virome analysis using RNAseq.

Derived from sampling site: Pleural effusion.

基因突变

Heterozygous for EGFR p.Cys251Tyr (c.752G>A) (PubMed=22675565; Cosmic-CLP).

Heterozygous for KIT p.Arg177His (c.530G>A) (PubMed=22675565; Cosmic-CLP).

Heterozygous for MET p.Arg191Trp (c.571C>T) (PubMed=22675565; Cosmic-CLP).

Heterozygous for PIK3CA p.Glu545Asp (c.1635G>T) and p.Glu970Lys (c.2908G>A) (PubMed=22675565; Cosmic-CLP).

Heterozygous for PTCH1 p.Arg682Cys (c.2044C>T) (PubMed=22675565; Cosmic-CLP).

Heterozygous for SPRY4 p.Arg48Trp (c.142C>T) (PubMed=22675565; Cosmic-CLP).

Heterozygous for TP53 p.Arg267Leu (c.800G>T) (PubMed=22675565; Cosmic-CLP).

HLA信息

STR信息

Amelogenin        X,Y (ATCC; Cosmic-CLP)

X (DSMZ)

CSF1PO        10,11

D5S818        11,12 (ATCC; Cosmic-CLP)

10,11,12 (DSMZ)

D7S820        11

D13S317        11,12 (ATCC; Cosmic-CLP)

10,11,12 (DSMZ)

D16S539        9,11,12 (ATCC; Cosmic-CLP)

9,10,11 (DSMZ)

TH01        9.3

TPOX        9 (ATCC; Cosmic-CLP)

8,9 (DSMZ)

vWA        16,18 (ATCC; Cosmic-CLP)

16,18,19 (DSMZ)

参考文献

PubMed=30285677; DOI=10.1186/s12885-018-4840-5

Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747

Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3

Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Nature 569:503-508(2019)