人B淋巴瘤细胞BJAB

细胞名称

人B淋巴瘤细胞BJAB

货物编码

BFN60806613

产品规格

T25培养瓶x1

1.5ml冻存管x2

细胞数量

1x10^6

1x10^6

保存温度

37℃

-198℃

运输方式

常温保温运输

干冰运输

安全等级

1

用途限制

仅供科研           2类

培养体系

DMEM高糖+10%FBS+1%双抗

培养温度

37℃

二氧化碳浓度

5%

简介

人B淋巴瘤细胞BJAB取自5岁女性供体。悬浮培养。该细胞源于DSMZ

序列突变

KMT2A-CLTC gene fusion (PubMed=31160637).

TP53 p.His193Arg (c.578A>G) (PubMed=1915267; PubMed=8344493).

注释

Part of: LL-100 blood cancer cell line panel.

Characteristics: EBV-negative. Even so that the original tumor tissue was infected with the B95-8 strain of EBV.

Doubling time: ~22 hours (PubMed=179629); ~40-60 hours (DSMZ).

Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).

Omics: Deep exome analysis.

Omics: Deep RNAseq analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis.

STR信息

Amelogenin        X

CSF1PO        8,10

D3S1358        16

D5S818        12,13

D7S820        10,11

D8S1179        15

D13S317        9,11

D16S539        9,11

D18S51        16,22

D21S11        27,28

FGA        27,28

Penta D        10,11

Penta E        7

TH01        7

TPOX        6,9

vWA        14,15 (DSMZ)

14,16 (PubMed=25877200)

参考文献

PubMed=8515068

Jain V.K., Judde J.-G., Max E.E., Magrath I.T.

Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation.

J. Immunol. 150:5418-5428(1993)

PubMed=8558920

Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M., Quentmeier H., Drexler H.G.

The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.

Leukemia 10:142-149(1996)

PubMed=23292937; DOI=10.1073/pnas.1205299110

Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Mieczkowski P.A., Dunphy C., Choi W., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C., Naresh K., Evens A., Gordon L.I., Czader M.B., Gill J.I., Hsi E.D., Liu Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J., Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S., Dunson D.B., Dave S.S.

Genetic heterogeneity of diffuse large B-cell lymphoma.

Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)

PubMed=25485619; DOI=10.1038/nbt.3080

Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.

A comprehensive transcriptional portrait of human cancer cell lines.

Nat. Biotechnol. 33:306-312(2015)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x

Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.

The LL-100 panel: 100 cell lines for blood cancer studies.

Sci. Rep. 9:8218-8218(2019)