人脑髓母细胞瘤细胞ONS-76
BLUEFBIO™ Product Sheet
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细胞名称 |
人脑髓母细胞瘤细胞ONS-76 |
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货物编码 |
BFN60808588 |
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产品规格 |
T25培养瓶x1 |
1.5ml冻存管x2 |
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细胞数量 |
1x10^6 |
1x10^6 |
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保存温度 |
37℃ |
-198℃ |
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运输方式 |
常温保温运输 |
干冰运输 |
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安全等级 |
1 |
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用途限制 |
仅供科研 3类 |
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培养体系 |
DMEM高糖培养基+10%FBS+1%三抗 |
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培养温度 |
37℃ |
二氧化碳浓度 |
5% |
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简介 |
人脑髓母细胞瘤细胞ONS-76取自2岁女性供体。该细胞源于JCRB |
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注释 |
Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Doubling time: 18.6 hours (CelloPub=CLPUB00094; PubMed=2504489; PubMed=2818910); ~24 hours (lot 08192008), ~32 hours (lot 12042014) (JCRB). Microsatellite instability: Stable (MSS) (Sanger). Omics: Deep exome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: SNP array analysis. Omics: Transcriptome analysis. |
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基因突变 |
Heterozygous for NRAS p.Gln61Arg (c.182A>G) (CCLE; Cosmic-CLP). TERT c.228C>T (-124C>T); in promoter (PubMed=31068700). Has no TP53 mutation (CCLE; Cosmic-CLP). |
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HLA信息 |
/ |
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STR信息 |
Amelogenin X CSF1PO 10,12 D2S1338 17,19 D3S1358 15 D5S818 9,10 D7S820 11,12 D8S1179 10 D13S317 8,13 D16S539 9,10 D18S51 14,21 D19S433 14,15.2 D21S11 29,30.3 FGA 24 Penta D 12,13 Penta E 15,16 TH01 9 TPOX 8 vWA 14,16 |
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参考文献 |
PubMed=22951319; DOI=10.1093/jrr/rrs078 Sun L., Moritake T., Zheng Y.W., Suzuki K., Gerelchuluun A., Hong Z., Zenkoh J., Taniguchi H., Tsuboi K. In vitro stemness characterization of radio-resistant clones isolated from a medulloblastoma cell line ONS-76. J. Radiat. Res. 54:61-69(2013)
PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J. A landscape of pharmacogenomic interactions in cancer. Cell 166:740-754(2016)
PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028 Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M. In vitro models of medulloblastoma: Choosing the right tool for the job. J. Biotechnol. 236:10-25(2016)
PubMed=27812533; DOI=10.1016/j.dib.2016.10.004 Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M. Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines. Data Brief 9:696-698(2016)
PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A. An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines. Cancer Res. 79:1263-1273(2019)
PubMed=31068700; DOI=10.1038/s41586-019-1186-3 Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature 569:503-508(2019)
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