人脑髓母细胞瘤细胞UW228

细胞名称

人脑髓母细胞瘤细胞UW228

货物编码

BFN60808589

产品规格

T25培养瓶x1

1.5ml冻存管x2

细胞数量

1x10^6

1x10^6

保存温度

37℃

-198℃

运输方式

常温保温运输

干冰运输

安全等级

1

用途限制

仅供科研      3类

培养体系

DMEM高糖培养基+10%FBS+1%三抗

培养温度

37℃

二氧化碳浓度

5%

简介

人脑髓母细胞瘤细胞UW228取自9岁女性供体。

注释

Omics: Deep exome analysis.

基因突变

TP53 p.Thr155Asn (c.464C>A) (PubMed=18505928; DepMap).

HLA信息

/

STR信息

参考文献

PubMed=18505928; DOI=10.1158/1541-7786.MCR-07-2105

Lo H.-W., Stephenson L., Cao X., Milas M., Pollock R., Ali-Osman F.

Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene.

Mol. Cancer Res. 6:843-850(2008)

PubMed=20847082; DOI=10.1093/neuoncq091

Teider N., Scott D.K., Neiss A., Weeraratne S.D., Amani V.M., Wang Y., Marquez V.E., Cho Y.-J., Pomeroy S.L.

Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.

Neuro-oncol. 12:1244-1256(2010)

PubMed=21177782; DOI=10.1093/neuoncq179

Weeraratne S.D., Amani V., Neiss A., Teider N., Scott D.K., Pomeroy S.L., Cho Y.-J.

miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.

Neuro-oncol. 13:165-175(2011)

PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281

Bandopadhayay P., Bergthold G., Nguyen B., Schubert S., Gholamin S., Tang Y., Bolin S., Schumacher S.E., Zeid R., Masoud S., Yu F., Vue N., Gibson W.J., Paolella B.R., Mitra S.S., Cheshier S.H., Qi J., Liu K.-W., Wechsler-Reya R., Weiss W.A., Swartling F.J., Kieran M.W., Bradner J.E., Beroukhim R., Cho Y.-J.

BET bromodomain inhibition of MYC-amplified medulloblastoma.

Clin. Cancer Res. 20:912-925(2014)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028

Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.

In vitro models of medulloblastoma: Choosing the right tool for the job.

J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004

Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.

Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.

Data Brief 9:696-698(2016)